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Fig. 5 | Diabetology & Metabolic Syndrome

Fig. 5

From: Semaglutide restores astrocyte–vascular interactions and blood–brain barrier integrity in a model of diet-induced metabolic syndrome

Fig. 5

Graphical representation of the AngioTool analysis of cerebral cortex sections (A) and hippocampal sections (D) from mice fed a high-fat (HFD) or normolipid (ND) diet and treated subcutaneously with 0.2 mg/kg/day semaglutide (SEMA) or saline solution (SAL). Average vessel length in the cortical area and hippocampus (B and E) and lacunarity in the cortical area and hippocampus (C and F). The skeleton is shown in red, and the branching points are shown in blue. Vessels labeled with IB4. Magnification: 400x; scale bar, 50 µm for all images. n = 6. *p < 0.05 versus the ND SAL group; #p < 0.05 versus the HFD SAL group

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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