Effects of acupuncture on the insulin signaling pathway and mitochondrial AMPK pathway in an animal model of type 2 diabetes mellitus: systematic evaluation and meta-analysis

Table 4 Subgroup analysis of intervention method

Outcomes	Acupuncture			Electroacupuncture			Total
	I²%	P	MD/SDM[95%CI]	I²%	P	MD/SDM[95%CI]	I²%	P	MD/SDM[95%CI]
FBG change	94	<0.00001	−12.07[−14.88,−9.26]	91	<0.00001	−6.72[−8.58,−4.85]	97	0.002	−8.14[−10.44,−5.84]
OGTT-AUC change	0	<0.00001	−9.12[−11.41,−6.83]	92	0.01	−9.08[−16.36,−1.79]	90	0.99	−9.06[−12.23,−3.90]
ISI	0	<0.00001	1.27[1.19,1.35]	100	0.01	0.75[−0.17,1.67]	100	0.27	0.85[0.09,1.62]
IRS-1 mRNA	0	0.04	0.44[0.02,0.86]	91	0.01	0.88[0.19,1.56]	88	0.29	0.78[0.26,1.31]
PI3K p85	74	<0.00001	0.21[0.15,0.27]	89	<0.00001	0.21[0.13,0.28]	88	0.98	0.21[0.16,0.26]

ISSN: 1758-5996