Effects of acupuncture on the insulin signaling pathway and mitochondrial AMPK pathway in an animal model of type 2 diabetes mellitus: systematic evaluation and meta-analysis

Table 7 Subgroup analysis of sample site

Outcomes	Skeletal muscle			Liver			Brain			Pancreatic			Total
	I²%	P	MD/SDM[95%CI]	I²%	P	MD/SDM[95%CI]	I²%	P	MD/SDM[95%CI]	I²%	P	MD/SDM[95%CI]	I²%	P	MD/SDM[95%CI]
IRS-1 mRNA	68	0.00001	0.96[0.54,1.39]	0	0.03	0.2[0.02,0.38]							88	0.001	0.79[0.29,1.29]
p-IRS-1	83	0.004	−1.45[−2.45,−0.45]	0	<0.00001		100	<0.00001	−0.61[−0.7,−0.52]				98	<0.00001	−0.80[−1.27,−0.32]
PI3K p85	80	<0.00001	0.26[0.24,0.28]	0	<0.00001	0.16[0.13,0.18]	0	0	0.12[0.07,0.17]	0	<0.00001	0.17[0.13,0.22]	88	<0.00001	0.21[0.19,0.22]

ISSN: 1758-5996